a tool for identifying drug-targetable redox-active disulphides

Defensin alpha 4

Intramolecular

Cysteine 71 and cysteine 88

A redox-regulated disulphide may form within Defensin alpha 4 between cysteines 71 and 88 (11 and 28 respectively in this structure).

Details

Redox score ?

87

PDB code

Structure name

solution structure of cryptdin-4, the most potent alpha-defensin from mouse paneth cells

Structure deposition date

2004-06-25

Thiol separation (Å)

2

Half-sphere exposure sum ?

46

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

71

Residue number B

88

Peptide name

Defensin alpha 4

Ligandability

Cysteine 71 of Defensin alpha 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Defensin alpha 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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